Kind of...maybe..probably not. So many of the features require the thermostat to have connectivity that it would likely be better to pursue a non-connected thermostat. It won't update for newest features, patches, code changes. You won't be able to configure much of it (how much depends on model). You won't be able to adjust temperatures remotely. You won't be able to integrate it into smart home features. The list goes on and on. I'm not even sure if you would get through the initial installation.
There are articles on the internet for how to use a Nest without Wi-Fi. I read through a few. Personally, I would not use a Nest thermostat without Wi-Fi. Seems like an exercise in frustration.
I am not a Google employee, just someone who likes Nest products and is trying to help folks get theirs working. The above is just one person's opinion.
